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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN22
All Species:
4.55
Human Site:
S546
Identified Species:
10
UniProt:
Q9Y2R2
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2R2
NP_057051.3
807
91705
S546
S
W
P
P
S
G
T
S
S
K
M
S
L
D
L
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S546
S
W
P
P
S
G
T
S
S
K
M
S
L
D
L
Rhesus Macaque
Macaca mulatta
XP_001110241
807
91482
G546
S
W
P
P
S
G
T
G
S
K
M
S
L
D
L
Dog
Lupus familis
XP_540240
893
101055
G631
S
L
S
P
S
S
A
G
S
K
M
S
L
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P29352
802
89696
N542
Y
F
S
S
S
P
P
N
S
A
D
S
K
M
S
Rat
Rattus norvegicus
NP_001099930
804
89584
P542
D
P
Y
F
S
S
S
P
P
N
S
A
G
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506530
800
89754
L536
E
L
E
M
K
D
P
L
L
P
L
G
S
Q
L
Chicken
Gallus gallus
XP_001235234
775
85980
C516
R
Q
C
P
Y
H
Y
C
C
S
A
E
D
P
Y
Frog
Xenopus laevis
NP_001084841
660
74123
N401
L
N
N
P
T
D
L
N
E
N
Y
S
K
S
G
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
L311
S
E
V
T
D
G
T
L
Q
E
D
S
S
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
K565
K
P
T
R
N
L
E
K
S
K
S
E
G
D
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.5
71.1
N.A.
71.1
69.2
N.A.
57.1
50.8
36.3
34.3
N.A.
N.A.
N.A.
N.A.
28.2
Protein Similarity:
100
99.8
97
77.9
N.A.
80.4
79.3
N.A.
68
64
50.9
49.9
N.A.
N.A.
N.A.
N.A.
44.7
P-Site Identity:
100
100
93.3
66.6
N.A.
20
6.6
N.A.
6.6
6.6
13.3
26.6
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
93.3
66.6
N.A.
33.3
20
N.A.
13.3
6.6
26.6
33.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
10
0
0
10
10
10
0
0
0
% A
% Cys:
0
0
10
0
0
0
0
10
10
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
10
19
0
0
0
0
19
0
10
46
0
% D
% Glu:
10
10
10
0
0
0
10
0
10
10
0
19
0
0
10
% E
% Phe:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
37
0
19
0
0
0
10
19
0
10
% G
% His:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
10
0
0
10
0
46
0
0
19
0
10
% K
% Leu:
10
19
0
0
0
10
10
19
10
0
10
0
37
0
46
% L
% Met:
0
0
0
10
0
0
0
0
0
0
37
0
0
10
0
% M
% Asn:
0
10
10
0
10
0
0
19
0
19
0
0
0
0
0
% N
% Pro:
0
19
28
55
0
10
19
10
10
10
0
0
0
19
0
% P
% Gln:
0
10
0
0
0
0
0
0
10
0
0
0
0
10
0
% Q
% Arg:
10
0
0
10
0
0
0
0
0
0
0
0
0
0
10
% R
% Ser:
46
0
19
10
55
19
10
19
55
10
19
64
19
19
10
% S
% Thr:
0
0
10
10
10
0
37
0
0
0
0
0
0
0
0
% T
% Val:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
28
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
10
0
10
0
10
0
0
0
10
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _